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Science of Curiosity

High School Genetics Worksheets: Punnett Squares, Dihybrid Crosses & Pedigrees

Build your students’ confidence in genetics with four engaging worksheet sets that cover everything from basic Punnett squares to analyzing and creating pedigrees. These activities are designed to reinforce key genetics concepts through meaningful practice and problem-solving. Use the full collection as a comprehensive test review packet, or assign each worksheet set individually as students learn new topics throughout your genetics unit.

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Build your students’ confidence in genetics with four engaging worksheet sets that cover everything from basic Punnett squares to analyzing and creating pedigrees. These activities are designed to reinforce key genetics concepts through meaningful practice and problem-solving. Use the full collection as a comprehensive test review packet, or assign each worksheet set individually as students learn new topics throughout your genetics unit.

 

Genetics Worksheets Include:

  • Basic Punnett Squares
  • Non-Mendelian Traits (codominant, incomplete dominant, multiple allele, sex-linked)
  • Dihybrid and Two Trait Crosses
  • Pedigrees

 

Ten pages total.

 

Full teacher key for each!

 

Worksheets provide enough questions for meaningful skill practice without unnecessary repetition. Questions are clear, concise, and engaging, with real problem-solving scenarios that keep students interested while reinforcing genetics concepts.

 

Designed to conserve paper with an efficient, space-saving layout and no wasted pages!

 

Basic Punnett Squares Worksheet: 

Students will…

  • Practice making punnett squares and test crosses with dominant and recessive alleles.
  • Use and understand the terms homozygous, heterozygous, dominant, recessive, genotype, and phenotype

 

Non-Mendelian Traits Worksheet:

Students will…

  • Identify codominant, incomplete dominant, sex linked and multiple allele traits based on phenotypes
  • Complete punnett squares and determine the possible offspring outcomes

 

Dihybrid and Two Trait Crosses Worksheet:

Students will…

  • Determine the possible allele combinations for each two trait cross
  • Complete punnett squares and determine the possible offspring outcomes

 

Pedigrees Worksheet:

Students will…

  • Make pedigrees from family descriptions
  • Identify inheritance patterns: (dominant, recessive, and x-linked) using pedigree examples of real genetic diseases (cystic fibrosis, Huntington’s, hemophilia, sickle cell)
  • Read pedigrees and predict offspring outcomes

 

The whole resource is 100% editable!

 

Click here to see a preview of the Genetics Worksheets!

 

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